Gesellschaft Deutscher Chemiker (GDCh)

Safety & Selectivity in the Scale Up of Chemical Reactions


The aim of the course is to give lab chemists an understanding of the issues that need to be considered during the early stages of scale up to large laboratory scale equipment (10-20 litre vessels) / kilo lab. The course will concentrate on chemical safety and selectivity issues and include information on what safety testing equipment is available and the uses and limitations of this equipment. Attendees will learn how to identify potential problems whether they be thermal hazards or selectivity issues. Methods used by other companies for handling hazardous reagents and reactions will be described as well as alternative chemistry to circumvent these reactions and / or reagents.

Detailed Course Contents:

  • Introduction - The safety literature
  • Improving safety and selectivity in chemical reactions - Inherent safety, choosing the right synthetic route
  • Thermal Hazard Testing and Runaway Reactions - Principles of hazard testing - equipment and uses
  • Solvent Selection and Solvent Effects - The effect of solvents on chemical reactions
  • Oxidation and reduction - Safety issues
  • Hazardous Reactions and Reagents - Azides, diazo compounds, Grignard Reagents
  • Work Up - Quenching reactions / reagents
  • Scaling up chemical reactions - What can go wrong - it's not what you do but the way that you do it - Simple do's and don't's
  • Case studies - Vilsmeier reaction, Grignard reaction, Azide chemistry

Target group:

Any laboratory chemist involved in the scale-up to large scale equipment / kilo lab.

» Details

Gesellschaft Deutscher Chemiker (GDCh)
Event Type:
04/19/2018 - 04/20/2018
Frankfurt am Main

Gesellschaft Deutscher Chemiker e.V.
Postfach 90 04 40
D-60444 Frankfurt am Main

Tel.: +49 (0)69 / 7917-364/-291
Fax: +49 (0)69 / 7917-475
Mail: Send request Contact